Controlling neural clustering using delayed inputs
Time Delay Systems, Volume # 8 | Part# 1
Authors
Orosz, Gábor; Moehlis, Jeff
Digital Object Identifier (DOI)
10.3182/20090901-3-RO-4009.00072
Page Numbers:
435-439
Index Terms
Hodgkin-Huxley model,signal transmission delay,bifurcation,event-based act-and-wait control
Abstract
Coupled Hodgkin-Huxley neurons are considered when finite-speed signal propagation introduces time delays into the coupling. Bifurcations of the fully synchronous and partially synchronized cluster states are studied by varying the coupling delay. Based on these investigations a controller is constructed that uses delayed inputs to destroy full synchrony and stabilize clustering. A generalization of such a controller may be useful to drive neural systems away from pathological synchronous states associated with Parkinson's disease.
References
[1] Ashwin, P. and Swift, J.W. (1992). The dynamics of n
weakly coupled identical oscillators. Journal of Nonlinear
Science, 2(1), 69-108.
[2] Bonnin, M., Corinto, F., and Gilli, M. (2007). Bifurcations,
stability and synchronization in delayed oscillatory networks.
International Journal of Bifurcation and Chaos,
17(11), 4033-4048.
[3] Brown, E., Holmes, P., and Moehlis, J. (2003). Globally
coupled oscillator networks. In E. Kaplan, J. Marsden,
and K. Sreenivasan (eds.), Perspectives and Problems in
Nonlinear Science: A Celebratory Volume in Honor of
Larry Sirovich, 183-215. Springer.
[4] Campbell, S.A. (2007). Time delays in neural systems. In
V.K. Jirsa and A.R. McIntosh (eds.), Handbook of Brain
Connectivity, Understanding Complex Systems, 65-90.
Springer.
[5] Coombes, S. and Laing, C. (2009). Delays in activity-based
neural networks. Philosophical Transactions of
The Royal Society A, 367(1891), 1117-1129.
[6] Danzl, P. and Moehlis, J. (2007). Event-based feedback
control of nonlinear oscillators using phase response
curves. In Proceedings of the 46th IEEE Conference on
Decision and Control, 5806-5811.
[7] Elble, R.J. and Koller, W.C. (1990). Tremor. Johns
Hopkins University Press.
[8] Ermentrout, B. and Ko, T.W. (2009). Delays and weakly
coupled neuronal oscillators. Philosophical Transactions
of The Royal Society A, 367(1891), 1097-1115.
[9] Hauptmann, C., Popovych, O., and Tass, P.A. (2007).
Demand-controlled desynchronization of oscillatory networks
by means of a multisite delayed feedback stimulation.
Computing and Visualization in Science, 10(2),
71-78.
[10] Hodgkin, A.L. and Huxley, A.F. (1952). A quantitative
description of membrane current and its application
to conduction and excitation in nerve. Journal of
Physiology, 117(4), 500-544.
[11] Insperger, T. (2006). Act-and-wait concept for continuous-time
control systems with feedback delay. IEEE Transactions
on Control Systems Technology, 14(5), 974-977.
[12] Izhikevich, E.M. (1998). Phase models with explicit time
delays. Physical Review E, 58(1), 905-908.
[13] Kiss, I.Z., Rusin, C.G., Kori, H., and Hudson, J.L. (2007).
Engineering complex dynamical structures: Sequential
patterns and desynchronization. Science, 316(5833),
1886-1889.
[14] Novák, B. and Tyson, J.J. (2008). Design principles of
biochemical oscillators. Nature Reviews Molecular Cell
Biology, 9(12), 981-991.
[15] Orosz, G. and Stépán, G. (2006). Subcritical Hopf bifurcations
in a car-following model with reaction-time
delay. Proceedings of the Royal Society of London A,
462(2073), 2643-2670.
[16] Roose, D. and Szalai, R. (2007). Continuation and bifurcation
analysis of delay differential equations. In
B. Krauskopf, H.M. Osinga, and J. Galan-Vioque (eds.),
Numerical Continuation Methods for Dynamical Systems,
359-399. Springer.
[17] Schöll, E., Hiller, G., Hövel, P., and Dahlem, M.A. (2009).
Time-delayed feedback in neurosystems. Philosophical
Transactions of The Royal Society A, 367(1891), 1079-
1096.
[18] Ullah, G. and Schiff, S.J. (2009). Tracking and control of
neuronal Hodgkin-Huxley dynamics. Physical Review E,
79(4), 040901(R).
