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Authors
McLoone, Violeta; Ringwood, John V.; Van Vliet, Bruce

Identifier
10.3182/20090812-3-DK-2006.00030

Index Terms
Biomedical signal processing; Circulatory and respiratory systems; Bioinformatics

Abstract
Salt-induced hypertension has been widely studied in rats, monkeys, chimpanzees and humans. Until recently, the multiple phases of this blood pressure increase due to high salt intake had not been closely studied. This work builds upon a recent study, which developed a grey-box multi-component model of salt-induced hypertension in the Dahl-S rat. The previous 3-component model has been extended here to include additional model dynamics to improve the model fit and add new important elements to the model response. The model was optimised using numerical techniques with experimental data from 4 different protocols with Dahl-S and hybrid rats. Results show a marked improvement over the previous model and confirm the merit of the 5-component model structure.

References

	References:

	Cholewa, B. and Mattson, D. (2001). Role of the reninangiotensin
	system during alterations of sodium intake
	in conscious mice. Am. J. Physiol. Regul. Integ. Comp.
	Physiol., 281, R987–R993.

	Dahl, L. (1961). Effects of chronic excess salt feeding. J.
	Exp. Med., 114, 231–236.

	Dahl, L. and Schackow, E. (1964). Effects of chronic excess
	salt ingestion: Experimental hypertension in the rat.
	Can Med Ass J., 90, 155–160.

	Denton, D., Weisinger, R., Mundy, N., Wickings, E.,
	Dixons, A., Moisson, P., Pingard, A., Shade, R., Carey,
	D., Ardaillou, R., Paillard, F., Chapman, J., Thillet, J.,
	and Michel, J. (1995). The effect of increased salt intake
	on blood pressure of chimpanzees. Nature Medicine, 1
	(10), 1009–1016.

	Lagarias, J., Reeds, J., Wright, M., and Wright, P. (1998).
	Convergence properties of the nelder-mead simplex
	method in low dimensions. SIAM Journal of Optimization,
	9 (1), 112–147.

	Ludden, T., Beal, S., and Sheiner, L. (1994). Comparison
	of the akaike information criterion, the schwarz criterion
	and the f test as guides to model selection. Journal of
	Pharmac. and Biopharm., 22 (5), 431–445.

	McLoone, V., Ringwood, J., and VanVliet, B. (2009).
	Multi-component mathematical model of salt sensitivity
	in dahl-s rats. Submitted to Hypertension.

	O’Shaughnessy, K. and Karet, F. (2006). Salt handling
	and hypertension. Ann. Rev. Nutr., 26, 343–365.

	Srinivasan, S., Berenson, G., Radhakrishnamurthy, B.,
	Dalferes, E., Underwood, D., and Foster, T. (1980).
	Effects of dietary sodium and sucrose on the induction
	of hypertension in spider monkeys. Am. J. Clin. Nutr.,
	33, 561–569.

	VanVliet, B., Chafe, L., S.Halfyard, and Leonard, A.
	(2006). Distinct rapid and slow phases of salt-induced
	hypertension in dahl salt-sensitive rats. J Hypertension,
	24.