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Authors
Fey, Dirk; Bullinger, Eric

Identifier
10.3182/20090706-3-FR-2004.00209

Index Terms
Biological Systems; Nonlinear System Identification; Continuous Time System Estimation

Abstract
Estimation of kinetic parameters is a key step in modelling biochemical reaction networks as, often, their direct estimation is expensive, time-consuming or even infeasible. This article proposes a parameter estimation procedure, which explicitly takes into account the model structure of the biological systems. The convergence is guaranteed using a dissipativity argument and a coordinate transformation yielding a parameter-free system description. The application to a basic enzyme kinetic model illustrates the proposed methodology.

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