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Authors
Sze-Wing Wong, Christos Georgakis, Gregory Botsaris, Kostas Saranteas, Roger Bakale

Identifier
None

Index Terms
calibration,prediction method,regression analysis,and spectra correlation

Abstract
This paper addresses the estimation of fractional composition of two diastereomers during crystallization. The estimation is obtained through a Partial Least Square (PLS) model that utilizes on-line Raman spectroscopy and additional process information such as temperature and slurry density. Several PLS models are developed that incorporate conditions that either neglect or account for variability in the additional process variables. It is argued that the model that incorporates both temperature and slurry density is the most accurate.

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