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Authors
Christopher E. Hann; Steen Andreassen; Bram W. Smith; Geoffrey M. Shaw; J. Geoffrey Chase; Per L. Jensen

Identifier
10.3182/20060329-3-AU-2901.00072

Index Terms
biomedical systems,physiological models,integrals,parameter identification,diagnosis

Abstract
A minimal cardiac model that accurately captures the essential cardiovascular system dynamics has been developed. Standard parameter identification methods for this model are highly non-linear and non-convex, hindering clinical application, given the limited measurements available in an intensive care unit. This paper presents an integral based identification method that transforms the problem into a linear, convex problem. Five common disease states including four fundamental types of shock, are identified to within 10% without false identification. Clinically, it enables medical staff to rapidly obtain a patient specific model to assist in diagnosis and therapy selection.

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